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The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches

Trivedi, Darshan V., Nag, Suman, Spudich, Annamma, Ruppel, Kathleen M., Spudich, James A.

Journal:

Annual Review of Biochemistry

Année:

2020

Langue:

english

Fichier:

PDF, 2.00 MB

english, 2020

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

Sarkar, Saswata S., Trivedi, Darshan V., Morck, Makenna M., Adhikari, Arjun S., Pasha, Shaik N., Ruppel, Kathleen M., Spudich, James A.

Journal:

Science Advances

Année:

2020

Fichier:

PDF, 2.51 MB

2020

Enzymatic activities correlate with chimaeric substitutions at the actin-binding face of myosin

Uyeda, Taro Q. P., Ruppel, Kathleen M., Spudich, James A.

Journal:

Nature

Année:

1994

Fichier:

PDF, 438 KB

1994

Myosin motor function: structural and mutagenic approaches

Kathleen M. Ruppel, James A. Spudich

Journal:

Current Opinion in Cell Biology

Année:

1995

Langue:

english

Fichier:

PDF, 506 KB

english, 1995

Myosin structure/function: a combined mutagenesis-crystallography approach

Kathleen M Ruppel, Michael Lorenz, James A Spudich

Journal:

Current Opinion in Structural Biology

Année:

1995

Langue:

english

Fichier:

PDF, 575 KB

english, 1995

Purification of a Functional Recombinant Myosin Fragment from Dictyostelium discoideum

KATHLEEN M. RUPPEL, THOMAS T. EGELHOFF, JAMES A. SPUDICH

Journal:

Annals of the New York Academy of Sciences

Année:

1990

Langue:

english

Fichier:

PDF, 794 KB

english, 1990

Improved Loaded In Vitro Motility Assay and Actin Filament Tracking Software Delineates the Effect of Hypertrophic and Dilated Cardiomyopathy Mutations on the Power Output of Cardiac Myosin

Aksel, Tural, Kawana, Masataka, Adhikari, Arjun, Sutton, Shirley, Ruppel, Kathleen, Spudich, James

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 45 KB

english, 2014

Understanding the Effects of Cardiomyopathy Causing Mutations on Human Beta Cardiac Myosin Biomechanical Function

Nag, Suman, Sommese, Ruth, Sung, Jongmin, Choe, Elizabeth, Kawana, Masataka, Cho, Carol, Taylor, Rebecca, Liu, Chao, Sutton, Shirley, Ruppel, Kathleen, Spudich, James

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 61 KB

english, 2014

Molecular genetic approaches to the cytoskeleton in Dictyostelium

Patterson, Bruce, Ruppel, Kathleen M., Spudich, James A.

Journal:

Current Opinion in Genetics & Development

Année:

1991

Langue:

english

Fichier:

PDF, 489 KB

english, 1991

STRUCTURE-FUNCTION ANALYSIS OF THE MOTOR DOMAIN OF MYOSIN

Ruppel, Kathleen M., Spudich, James A.

Journal:

Annual Review of Cell and Developmental Biology

Année:

1996

Langue:

english

Fichier:

PDF, 931 KB

english, 1996

Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules

Sung, Jongmin, Nag, Suman, Mortensen, Kim I., Vestergaard, Christian L., Sutton, Shirley, Ruppel, Kathleen, Flyvbjerg, Henrik, Spudich, James A.

Journal:

Nature Communications

Année:

2015

Langue:

english

Fichier:

PDF, 602 KB

english, 2015

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

Aksel, Tural, Choe Yu, Elizabeth, Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.

Journal:

Cell Reports

Année:

2015

Langue:

english

Fichier:

PDF, 2.93 MB

english, 2015

The Effect of Pediatric Specific Hypertrophic Cardiomyopathy Mutations on the Biomechanics of Beta Cardiac Myosin

Adhikari, Arjun S., Bezold Kooiker, Kristina, Sutton, Shirley, Bernstein, Daniel, Leinwand, Leslie A., Ruppel, Kathleen M., Spudich, James A.

Journal:

Biophysical Journal

Année:

2016

Langue:

english

Fichier:

PDF, 48 KB

english, 2016

On the Molecular Basis of Monogenic Human Hypertrophic and Dilated Cardiomyopathies

Spudich, James, Nag, Suman, Sutton, Shirley, Sarkar, Saswata, Taylor, Rebecca, Trivedi, Darshan, Liu, Chao, Adhikari, Arjun, Ruppel, Kathleen

Journal:

Biophysical Journal

Année:

2016

Langue:

english

Fichier:

PDF, 33 KB

english, 2016

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

Homburger, Julian R., Green, Eric M., Caleshu, Colleen, Sunitha, Margaret S., Taylor, Rebecca E., Ruppel, Kathleen M., Metpally, Raghu Prasad Rao, Colan, Steven D., Michels, Michelle, Day, Sharlene M.

Journal:

Proceedings of the National Academy of Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2016

Effects of Hypertrophic Cardiomyopathy Causing R403Q Mutation on Human Beta-Cardiac Myosin Biomechanical Function: Single Molecule to Ensemble Studies

Nag, Suman, Sommese, Ruth, Sutton, Shirley, Ruppel, Kathleen, Spudich, James

Journal:

Biophysical Journal

Année:

2015

Langue:

english

Fichier:

PDF, 45 KB

english, 2015

Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin

Pan, Stephen, Sommese, Ruth F., Sallam, Karim I., Nag, Suman, Sutton, Shirley, Miller, Susan M., Spudich, James A., Ruppel, Kathleen M., Ashley, Euan A.

Journal:

BMC Medical Genetics

Année:

2015

Langue:

english

Fichier:

PDF, 1.85 MB

english, 2015

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin

Adhikari, Arjun S., Kooiker, Kristina B., Sarkar, Saswata S., Liu, Chao, Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.

Journal:

Cell Reports

Année:

2016

Langue:

english

Fichier:

PDF, 2.06 MB

english, 2016

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

Kawana, Masataka, Sarkar, Saswata S., Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.

Journal:

Science Advances

Année:

2017

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2017

Uncovering the Molecular Interactions that Maintain the Sequestered State of Myosin and their Implication in Hypertrophic Cardiomyopathy

Trivedi, Darshan V., Nag, Suman, Sarkar, Saswata S., Adhikari, Arjun S., Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.

Journal:

Biophysical Journal

Année:

2017

Langue:

english

Fichier:

PDF, 44 KB

english, 2017

Investigation of the Molecular Interactions Regulating the Function of Human Cardiac Myosin

Sarkar, Saswata S., Trivedi, Darshan, Adhikari, Arjun S., Liu, Chao, Ruppel, Kathleen M., Spudich, James A.

Journal:

Biophysical Journal

Année:

2017

Langue:

english

Fichier:

PDF, 42 KB

english, 2017

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A

Journal:

Nature Structural and Molecular Biology

Année:

2017

Langue:

english

Fichier:

PDF, 3.21 MB

english, 2017

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light

Trivedi, Darshan V., Adhikari, Arjun S., Sarkar, Saswata S., Ruppel, Kathleen M., Spudich, James A.

Journal:

Biophysical Reviews

Année:

2017

Langue:

english

Fichier:

PDF, 3.97 MB

english, 2017

Impact of Hypertrophic Cardiomyopathy Mutations and the Role of Myosin Binding Protein-C on the Sequestered State of Myosin

Trivedi, Darshan V., Sarkar, Saswata S., Morck, Makenna M., Adhikari, Arjun A., Ruppel, Kathleen M., Spudich, James A.

Journal:

Biophysical Journal

Année:

2018

Langue:

english

Fichier:

PDF, 41 KB

english, 2018

Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level

Liu, Chao, Kawana, Masataka, Song, Dan, Ruppel, Kathleen M., Spudich, James A.

Journal:

Nature Structural and Molecular Biology

Année:

2018

Langue:

english

Fichier:

PDF, 2.83 MB

english, 2018

Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human β-Cardiac Myosin

Sommese, Ruth F., Nag, Suman, Sutton, Shirley, Miller, Susan M., Spudich, James A., Ruppel, Kathleen M., Kimura, Akinori

Journal:

PLoS ONE

Année:

2013

Langue:

english

Fichier:

PDF, 495 KB

english, 2013

Controlling Cardiac Contractility at the Single Molecule Level

Liu, Chao, Song, Dan L., Kawana, Masataka, Ruppel, Kathleen M., Spudich, James A.

Journal:

Biophysical Journal

Année:

2018

Langue:

english

Fichier:

PDF, 45 KB

english, 2018

Mechanobiology of Myosin Mutations and Myofibril Remodeling in iPSC-Cardiomyocytes

Schroer, Alison, Kooiker, Kristina, Adhikari, Arjun, Ruppel, Kathleen, Bernstein, Daniel, Spudich, James, Pruitt, Beth

Journal:

Biophysical Journal

Année:

2018

Langue:

english

Fichier:

PDF, 58 KB

english, 2018

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.

Journal:

Nature Communications

Année:

2019

Langue:

english

Fichier:

PDF, 2.92 MB

english, 2019

Hypertrophic Cardiomyopathy Mutations Disrupt Human Beta Cardiac Myosin Intramolecular Interactions Leading to Increased Myosin Activity

Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Ruppel, Kathleen M., James, Spudich A.

Journal:

Biophysical Journal

Année:

2018

Fichier:

PDF, 41 KB

2018

A Molecular Approach to Understand the Super-Relaxed State of Myosin Observed in Cardiac Muscle

Sarkar, Saswata S., Trivedi, Darshan V., Morck, Makenna M., Adhikari, Arjun S., Ruppel, Kathleen M., Spudich, James A.

Journal:

Biophysical Journal

Année:

2018

Langue:

english

Fichier:

PDF, 39 KB

english, 2018

Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties

Vera, Carlos D., Johnson, Chloe A, Walklate, Jonathan, Adhikari, Arjun, Svicevic, Marina, Mijailovich, Srbolujub M, Combs, Ariana C., Langer, Stephen J., Ruppel, Kathleen M., Spudich, James A, Geeves,

Journal:

Journal of Biological Chemistry

Année:

2019

Langue:

english

Fichier:

PDF, 2.09 MB

english, 2019

Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties

Journal:

Journal of Biological Chemistry

Année:

2019

Fichier:

PDF, 2.09 MB

2019

Study of Hcm Causing Î²-Cardiac Myosin Mutations Located at Different Structurally Significant Regions of the Myosin-Head

Bhowmik, Debanjan, Nandwani, Neha, Ruppel, Kathleen, Liu, Chao, Spudich, James A.

Journal:

Biophysical Journal

Année:

2020

Fichier:

PDF, 46 KB

2020

Uncovering the Molecular and Structural Basis of Hypertrophic Cardiomyopathy-Causing Mutations in Myosin and Myosin Binding Protein-C

Nandwani, Neha, Trivedi, Darshan V., Sarkar, Saswata S., Morck, Makenna, Ruppel, Kathleen, Spudich, James A.

Journal:

Biophysical Journal

Année:

2020

Fichier:

PDF, 46 KB

2020

Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness

Gyimesi, MÃ¡tÃ©, HorvÃ¡th, ÃdÃ¡m I., TÃºrÃ³s, Demeter, Suthar, Sharad Kumar, PÃ©nzes, MÃ¡tÃ©, Kurdi, Csilla, Canon, Louise, Kikuti, Carlos, Ruppel, Kathleen M., Trivedi, Darshan V., Spudich, James A.

Journal:

Cell

Année:

2020

Fichier:

PDF, 8.80 MB

2020